LIAISON PLEX® and VERIGENE® NanoGrid Technology
NanoGrid Technology is the powerful driving force behind all LIAISON PLEX® and VERIGENE® assays
The LIAISON PLEX® and VERIGENE® systems utilize automation and proprietary chemistry to enable rapid, sample-to-result detection of nucleic acid targets. NanoGrid Technology, a unique gold nanoparticle probe chemistry, is the driving force behind all LIAISON PLEX and VERIGENE tests, providing a versatile and extremely reliable foundation for these systems.
How does NanoGrid Technology work?
The gold nanoparticles are 13-20 nanometers in diameter. Each nanoparticle is functionalized with either a defined number of oligonucleotides or antibodies that are specific to a particular nucleic acid of interest.
NanoGrid Technology benefits
The LIAISON PLEX® and VERIGENE® systems using NanoGrid Technology entails
- Nucleic acid extraction and direct detection or PCR amplification
- Hybridization of target DNA on a microarray
- Hybridization of specific mediator oligonucleotides and gold nanoparticle probes
- Signal amplification of hybridized probes via a silver staining process
- Automated qualitative analysis of results
Gold nanoparticle probes are ideal for diagnostic applications
- Allow increased sensitivity by several orders of magnitude compared to fluorophores
- Enable high specificity nucleic acid detection
- Reduce background noise, creating an enhanced assay signal
- Are extremely stable, have a long shelf-life, and are non-toxic